“We don’t have a way to know the subjective experience of an insect,” says Slot, and it’s hard to say if they trip.
““We don’t have a way to know the subjective experience of an insect,” says Slot, and it’s hard to say if they trip.”
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Posts tagged psychedelics
Horizontal gene cluster transfer increased hallucinogenic mushroom diversity
Secondary metabolites are heterogeneous natural products that often mediate interactions between species. The tryptophan-derived secondary metabolite, psilocin, is a serotonin receptor agonist that induces altered states of consciousness. A phylogenetically disjunct group of mushroom-forming fungi in the Agaricales produce the psilocin prodrug, psilocybin. Spotty phylogenetic distributions of fungal compounds are sometimes explained by horizontal transfer of metabolic gene clusters among unrelated fungi with overlapping niches. We report the discovery of a psilocybin gene cluster in three hallucinogenic mushroom genomes, and evidence for its horizontal transfer between fungal lineages. Patterns of gene distribution and transmission suggest that psilocybin provides a fitness advantage in the dung and late wood-decay niches, which may be reservoirs of fungal indole-based metabolites that alter behavior of mycophagous and wood-eating invertebrates. These hallucinogenic mushroom genomes will serve as models in neurochemical ecology, advancing the prospecting and synthetic biology of novel neuropharmaceuticals.
Researchers use music and LSD to understand how we attribute meaning.
Attribution of meaning and personal relevance is important for our everyday lives. In psychiatric disorders, the attribution of meaning is often altered, and the mechanisms causing this were unknown. LSD has also been shown to alter the attribution of meaning and personal relevance to the environment and our sense of self. However, the exact mechanism and brain structures had not been investigated yet. Therefore, LSD offered a unique opportunity to investigate these phenomena.
via https://www.researchgate.net/blog/post/lsd-unlocks-how-our-brains-impart-meaningfulness
Goodbye to the Godfather of Psychedelics
“Sasha’s work is by all objective criteria worthy of the very highest academic honors, Nobel Prize kind of stuff, but such honors are impossible as we struggle as a society to learn how to balance the complexities that are stirred up by the power of psychedelics,” said UC Berkeley neurobiology lecturer David Presti during the hour-long memorial service. “It was too big to be done in a multimillion dollar laboratory. It instead required an alchemist’s den, a courageous spirit, a careful focus of intention, and a goodly dose of mystical insight. Then the stuff of legend happened. Thank you, Sasha.”
The drug revolution that no one can stop
Many of those who design drugs do so merely to push the boundaries: these “psychonauts” as they are sometimes known, are early adopters of new drugs. Some share their knowledge freely and collaboratively; some are intensely geeky; some are pretentious and elitist chemical grandstanders, eager to be the first to try and document any new drug. Many psychonauts are extremely cautious, and fastidious in dosing and documenting a drug’s effects. Others still are reckless risk-takers—people who will try anything for a kick. One user I spoke to enjoyed his experiences with mushrooms so much that he began to seek out all the new hallucinogens he could find. He is a passionate advocate for psychedelics: “In life, you’re battling through the undergrowth and every so often it’s good to climb a tall tree to get your bearings. This is what psychedelics do for me.”