Posts tagged astrocytes
LEHRER: You suggest that glia and their calcium waves might play a role in creativity. Could you explain? KOOB: This idea stems from dreams, sensory deprivation and day dreaming. Without input from our senses through neurons, how is it that we have such vivid thoughts? How is it that when we are deep in thought we seemingly shut off everything in the environment around us? In this theory, neurons are tied to our muscular action and external senses. We know astrocytes monitor neurons for this information. Similarly, they can induce neurons to fire. Therefore, astrocytes modulate neuron behavior. This could mean that calcium waves in astrocytes are our thinking mind. Neuronal activity without astrocyte processing is a simple reflex; anything more complicated might require astrocyte processing. The fact that humans have the most abundant and largest astrocytes of any animal and we are capable of creativity and imagination also lends credence to this speculation. Calcium is also released randomly and without stimulation from astrocytes’ internal stores in small bursts called ‘puffs.’ These random puffs can lead to waves. It is possible that the seemingly random thoughts during dreams and sensory deprivation experience could be calcium puffs becoming waves in our astrocytes. Basically, it is obvious that astrocytes are involved in brain processing in the cortex, but the main questions are, do our thoughts and imagination stem from astrocytes working together with neurons, or are our thoughts and imagination solely the domain of astrocytes? Maybe the role of neurons is to support astrocytes.